- PM2.5
- Fine particulate matter with a diameter of 2.5 micrometers or less; a key marker of air pollution health risk because these tiny particles can penetrate deep into the lungs and bloodstream.
- AQI (Air Quality Index)
- A standardized scale used by governments to communicate how polluted the air is on a given day and what associated health concerns may exist for the public.
- Hazard ratio
- A statistical measure comparing the rate of an outcome (e.g., cancer) in an exposed group versus an unexposed group; a hazard ratio of 1.3 means 30% higher risk.
- Randomized controlled trial (RCT)
- A study design where participants are randomly assigned to intervention or control groups to minimize confounding; the gold standard for establishing causality in medicine.
- Confounding
- A distortion in an observational study where an unmeasured third variable is associated with both the exposure and the outcome, making causal claims unreliable.
- Lp(a) (lipoprotein(a))
- A genetically determined lipoprotein particle that is a causal risk factor for cardiovascular disease; Peter Attia uses it as an example of a stable, reliably measurable biomarker.
- EMF (electromagnetic field)
- Fields produced by electrically charged objects; in health contexts usually refers to radiofrequency electromagnetic fields emitted by phones, Wi-Fi routers, and cellular towers.
- 5G
- The fifth generation of cellular network technology, operating at higher radiofrequency bands than 4G; discussed in the context of whether its EMF emissions pose health risks.
- Ionizing radiation
- High-energy radiation (e.g., X-rays, gamma rays) with enough energy to remove electrons from atoms and damage DNA; distinct from the non-ionizing radiation of EMF/5G.
- Non-ionizing radiation
- Lower-energy electromagnetic radiation (e.g., radio waves, microwaves, visible light) that does not carry enough energy to ionize atoms or directly break chemical bonds.
- Particulate matter
- A mixture of solid particles and liquid droplets suspended in air; classified by size (PM10, PM2.5) and a major component of air pollution with documented health effects.
- Natural experiment
- An observational study that exploits naturally occurring differences in exposure (e.g., people who happen to live near highways vs. rural areas) rather than researcher-imposed randomization.
- Armamentarium
- The complete range of equipment, treatments, or resources available for a particular purpose; Peter Attia uses it to mean 'toolkit of health interventions.'
- Hermetically sealed
- Completely airtight; Peter Attia uses the phrase 'hermetically closed bubble' as a metaphor for the impossibility and undesirability of eliminating all environmental exposures.
- Heterogeneity
- Variability or diversity within a dataset; here used to describe the wide variation in individual environmental exposures that makes zip-code-level epidemiological estimates imprecise.
- PFAS
- Per- and polyfluoroalkyl substances; a class of synthetic chemicals found in many consumer products, known for environmental persistence and potential health effects — covered in a prior AMA.
- Phthalates
- A group of chemicals used to make plastics more flexible; associated with endocrine disruption and covered in a prior AMA on chemical pollutants.
- Circadian rhythm
- The internal 24-hour biological clock that regulates sleep-wake cycles, hormone release, and other body functions; highly sensitive to light exposure timing.