Podbit · All-In with Chamath, Jason, Sacks & Friedberg
The Ark Institute, backed by the Collisons, ingested all available genomic data and built a genome language model that reads DNA sequences the way a language model reads sentences. It's already changing plant breeding at Ohalo. This is what community-funded open-source AI looks like when it works — and it's the antidote to closed-model monopolies.
Where this was said
At 19:55 · chapter starts 0:19
Fable 5 tops benchmarks but stores all prompts for 30 days, secretly downgrades AI researchers, and buries the policy in a 319-page document [1] — David Sacks "Anthropic's Fable 5 stores all your prompts for 30 days, secretly downgrades users it deems unworthy — including rewriting their prompts in…" 09:30 . Friedberg reveals his genomics lab is migrating to Chinese open-source AI as a result [2] — David Friedberg "Anthropic's safety restrictions have begun blocking legitimate gene-editing and genomics research at Ohalo, Friedberg's agricultural biotec…" 05:14 .
Anthropic's safety restrictions have begun blocking legitimate gene-editing and genomics research at Ohalo, Friedberg's agricultural biotech company. The result: they're migrating to Chinese open-source models. US AI over-restriction is directly handing China a competitive advantage.
David Friedberg noted that the best open-source models available today are Chinese, meaning US AI restrictions push companies toward Chinese AI tools.
Anthropic's Fable 5 stores all your prompts for 30 days, secretly downgrades users it deems unworthy — including rewriting their prompts in the background — while still charging full price. Enterprise customers with zero-retention agreements get no opt-out. This isn't a bug; it's the product.
Anthropic's Fable 5 stores every prompt and output — including from enterprise customers with zero-data-retention agreements — for at least 30 days, with no opt-out.
Anthropic isn't just worried about safety — it's running a sophisticated regulatory capture campaign. While surveilling users and downgrading competitors, Dario simultaneously blogs for a new FDA-style AI regulator. The target isn't dangerous actors; it's open-source alternatives.
Fable 5 would silently nerf its output for users Anthropic deemed unworthy — including rewriting prompts in the background — while still charging full price.
In Dan Ariely's door experiment, participants sacrificed the highest-reward door — repeatedly — just to avoid seeing other doors disappear. Even when researchers trained them to use the best door, they kept wasting clicks to maintain options. This is the bias that runs our lives: we'll take a worse outcome to preserve the feeling of optionality.
Dan Gilbert discovered that the brain has a 'psychological immune system' — it misremembers, reframes, and rationalizes to keep you satisfied with whatever you chose. The fear before commitment is all about potential regret. But after committing, your brain quietly starts justifying the choice — and the more irreversible the decision, the stronger the effect.
The psychological immune system can get you through the first few months of any commitment. But durable, long-term well-being requires self-concordance — choosing commitments that are genuinely aligned with your values and what you actually want. Without that alignment, the satisfaction fades fast.
Vision didn't just help animals find food — it ignited the Cambrian explosion of speciation. Half of the human cortex is devoted to visual processing, and that same visual hierarchy directly inspired the neural network architectures powering today's AI.
Peptides come loaded with a powerful narrative: regenerative, subcutaneous, targeted, cutting-edge. That narrative can genuinely move outcomes, especially for pain, energy, and recovery. The RCT's job is to quantify how much additional benefit comes from the molecule itself — above and beyond the compelling story surrounding it.
A pharmaceutical is not an amino acid sequence — it is the successful solution to manufacturing, purification, formulation, and consistency challenges. When clinical trials prove a drug works, they validate a specific product under specific processes, not every preparation that shares the same sequence.
Ask one question of any peptide advocate: what evidence would prove this claim wrong? If every disappointing result gets attributed to wrong dose, bad supplier, wrong timing, or improper stacking, the hypothesis is not falsifiable — and a non-falsifiable claim is not a scientific claim.
When you vividly imagine something, your visual, auditory, and motor cortices light up almost identically to when it actually happens. This means daily visualization is genuine neural training — not wishful thinking.
Reality has gaps — and you fill them with stories. When you meet someone new and instantly form an impression, that's not perception, it's imagination. Recognizing this is the first step to changing the story.
We use essential and analytics cookies to run Vuci. To understand how the site is used: Privacy Policy.
Install Vuci on your phone
Add it to your home screen for a faster, app-like experience.
Install Vuci on your phone
Tap the Share button, then “Add to Home Screen”.
A new version is available
Reload to get the latest Vuci.