The Diary Of A CEO with Steven Bartlett

Podbit · The Diary Of A CEO with Steven Bartlett

Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain Now

Explore episode Aug 7, 2026

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Zone 2 vs. Zone 5: What Women Need to Know

At 15:35 · chapter starts 12:40

The conversation turns to aerobic training and a contested debate that has polarised fitness social media: should you train in Zone 2 or not? Nicola defines the zones clearly: Zone 1 is rest, Zone 2 is around 60% of maximum heart rate (a conversational jog), while Zones 3–5 push into increasingly anaerobic territory. She explains the metabolic mechanics: Zone 2 operates within the mitochondria using fat as fuel, while higher zones push energy production into the cytoplasm via glycolysis, producing lactate — itself a myokine and brain fuel. Her recommendation surprises many: women in midlife should not default to Zone 2. Men extract a greater relative benefit from Zone 2 training than women do. For time-poor individuals in midlife, the priority order should be Zone 5 first, then 2–3 resistance training sessions, and only then Zone 2 if time allows. Zone 2 is not bad — it still produces BDNF and sustained brain blood flow. But it does not fully remodel the heart's chambers the way higher-intensity work does. Bartlett then raises the outdoor vs. treadmill question, and Nicola acknowledges outdoor running offers additional benefits: forward ambulation boosts dopamine and motivation, sensory stimulation engages broad swathes of the brain, and natural environments downregulate inflammation. But for pure brain return per minute, Zone 5 wins.

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