Podbit · All-In with Chamath, Jason, Sacks & Friedberg
Maris founded Calico, invested in Flatiron and New Limit, and remains deeply interested in longevity — but says therapeutic clinical trials are a specialist area he's stepping back from. The real prize is computational biology: simulate a human cell in silico and drug discovery accelerates exponentially.
Porn starts as naked curiosity at age 11 or 12, then quietly becomes the brain's go-to response for any pain — a bad grade, a rejection, a bad day at work. By the time you're 35, the wiring is so deep it's entirely unconscious. You're not choosing porn; your brain already made the decision.
Quitting porn takes three things working together: understanding you're medicating pain, not feeding a sex drive; a brotherhood of accountability so you realize your struggle isn't unique; and enough neuroscience to understand what the habit is actually doing to your brain. No single lever is enough on its own.
Guys spend their whole lives trying to defeat lust and never get to the harder stuff. Lust is actually the easy one. Once the porn goes, suddenly you're face-to-face with anger, cruelty, emotional unavailability — the vices that were hiding behind it the whole time.
Matt didn't quit because someone told him to. He ran a personal experiment and found out for himself. He passed the ultimate test — solo hotel weekends — a few times. Since then, the honest position has been: I've been on both sides, the side without porn is just better.
It's not anecdotal anymore. Research is increasingly showing that chronic porn use crushes productivity and output. Your brain spends its best resources on the habit, leaving you sluggish, low-energy, and less capable at work and at home.
Tom Segura says he had zero body insecurities at his heaviest. He only started questioning it when he looked back at photos and thought, 'Why didn't anyone say anything?' The disconnect between living happily in a fat body and the shock of hindsight is genuinely surprising.
Tom had hard, rock-solid visceral fat crammed around his organs. Bert had the softer, 'sit different' variety. Tom says he actually preferred his hard belly — people would poke it and say it felt like a rock. The distinction is funny, but visceral fat is the kind that presses on your heart.
Bert Kreischer's resting heart rate was 79 bpm in January, around the time he had a blood clot. Six months of sobriety later, it's in the low 50s. He shows Tom the Whoop sleep data too: a flat, uninterrupted line that looks almost medically perfect.
A JAMA Pediatrics study found 1 in 5 teens and young adults now turn to AI chatbots for mental health support, a number that shot up 40% in just one year. General-use tools like ChatGPT and Gemini weren't built for this — and there have been deaths. Psychologist Ursula Whiteside delivers the most important rebuttal to AI therapy in one sentence: human connection is what keeps people from suicide.
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