People at end-of-life rarely regret actions they took — they most commonly regret the things they did not do, particularly not living fully.
Snapshot · The School of Greatness
People at end-of-life rarely regret actions they took — they most commonly regret the things they did not do, particularly not living fully.
Where this was said
At 16:10 · chapter starts 13:00
This chapter pivots from personal reflection to bold philosophy. Lewis asks whether someone can fully experience love if they are unwilling to go through grief at the deepest level — and Kessler's answer is unequivocal: grief and love are a package deal, non-negotiable, and anyone who tries to play it safe gets less of both [1] — David Kessler "What we run from pursues us and what we face transforms us." 50:32 . He connects this directly to his work at end-of-life: people lying on their deathbeds consistently express regret not for the things they did but for the things they never dared [2] — David Kessler "We don't regret things we did: People at end-of-life rarely regret actions they took — they most commonly regret the things they did not do…" 16:10 . Playing safe, he argues, is actually the scariest thing a person could do — what a waste of life to arrive at the end with risks untaken and love unexpressed. The exchange is charged with urgency, as both Lewis and Kessler acknowledge their own periods of playing safe and the price they paid for it.
Avoiding grief isn't free — it's exhausting. Kessler's beach ball metaphor nails it: pushing a small balloon down is easy, but holding a massive beach ball underwater takes constant, draining energy. Unattended feelings don't disappear; they just consume you.
Making the first hour of your day high-cortisol and the last hour low-cortisol is described as the single most impactful daily habit for mood, focus, alertness, stress resilience, and sleep quality.
A Washington University in St. Louis study found that a great night's sleep produces attention-improvement effects effectively equal to Ritalin.
In the 4 to 6 hours after exercise, dopamine and norepinephrine are elevated, making you more alert and better able to focus — unless you've exercised to exhaustion.
The physiological sigh — two big inhales followed by a full exhale — was discovered by physiologists in the 1930s and is the fastest way to reduce autonomic arousal.
Doing just 10 deliberate exhales throughout the day can significantly elevate heart rate variability by the evening, by repeatedly activating the vagal sinoatrial node pathway.
For nicotine to have a genuine cognitive-enhancing effect rather than merely rescuing withdrawal deficit, Huberman recommends using it only once or twice per week at 3–6 mg.
Because vaping can be done anywhere and is more palatable, people consume far more nicotine via vaping than they ever did smoking, potentially making vaping more dangerous in aggregate despite being safer per puff.
Huberman reported that two injections of approximately 100–200 micrograms of BPC-157 eliminated persistent shoulder pain that had resisted months of other interventions.
Huberman reported that on nights he used the peptide pinealon, he achieved 2.5 to 3 hours of REM sleep inside 6 hours — an unusually high proportion normally only found in the final hours of longer sleep.
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