Chris currently takes four peptides: BPC-157 and TB500 for recovery, thymosin alpha for immune support, and SS31 for mitochondrial support.
Snapshot · Modern Wisdom
Chris currently takes four peptides: BPC-157 and TB500 for recovery, thymosin alpha for immune support, and SS31 for mitochondrial support.
Where this was said
At 1:39:00 · chapter starts 1:30:45
Two lighter questions open this chapter: a listener asks about Chris's changing hair (he has the follicular constitution of a 'golden doodle' with only two modes: short or curly), and another asks about his hairline (holding firm, unlike co-founder James Smith, whose genes are apparently 'just his genes'). The chapter pivots into substance when a listener asks about peptides. Chris confirms he's currently taking BPC-157 and TB-500 for recovery including bone regrowth after a tooth extraction, thymosin alpha for immune support, and SS-31 for mitochondrial support due to chronic fatigue. He discloses a much longer historical list — CMAX, FRAG23, PT-141 — and notes that TB-500 and BPC significantly helped his Achilles rehab six years ago. The disclaimer: much of the gray market peptide supply is adulterated, so be careful.
Making the first hour of your day high-cortisol and the last hour low-cortisol is described as the single most impactful daily habit for mood, focus, alertness, stress resilience, and sleep quality.
A Washington University in St. Louis study found that a great night's sleep produces attention-improvement effects effectively equal to Ritalin.
In the 4 to 6 hours after exercise, dopamine and norepinephrine are elevated, making you more alert and better able to focus — unless you've exercised to exhaustion.
The physiological sigh — two big inhales followed by a full exhale — was discovered by physiologists in the 1930s and is the fastest way to reduce autonomic arousal.
Doing just 10 deliberate exhales throughout the day can significantly elevate heart rate variability by the evening, by repeatedly activating the vagal sinoatrial node pathway.
For nicotine to have a genuine cognitive-enhancing effect rather than merely rescuing withdrawal deficit, Huberman recommends using it only once or twice per week at 3–6 mg.
Because vaping can be done anywhere and is more palatable, people consume far more nicotine via vaping than they ever did smoking, potentially making vaping more dangerous in aggregate despite being safer per puff.
Huberman reported that two injections of approximately 100–200 micrograms of BPC-157 eliminated persistent shoulder pain that had resisted months of other interventions.
Huberman reported that on nights he used the peptide pinealon, he achieved 2.5 to 3 hours of REM sleep inside 6 hours — an unusually high proportion normally only found in the final hours of longer sleep.
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