Snapshot · The Shawn Ryan Show
Brain-derived neurotrophic factors (BDNF) were found to be up 270% — three times baseline — in people who practised Sadhguru's simple process for just six to eight weeks.
Where this was said
At 1:33:50 · chapter starts 1:33:10
With his personal experience as prologue, Sadhguru turns to the science. Top universities have studied people doing his simple 21-minute practice for six to eight weeks and found: bliss factor up 70%; BDNF (brain-derived neurotrophic factors) up 270% — three times baseline; and bliss states 23% higher than those typically recorded during a sexual orgasm, simply from sitting still. He connects this to his original plan: at age 25, with the world's population at roughly 4.82 billion, he sat down with a world map and gave himself 2.5 years to make everyone blissful. Forty-four years later, population at 8.4 billion, he has touched around 2 billion people — and calls himself a blissful failure. His blessing for everyone: set goals so large that even falling short takes multiple lifetimes of effort. The mind, he insists, is the greatest miracle available — most people have turned it into a misery machine, but every single person without exception can reverse that. [1] — Sadhguru "A 21-minute daily practice raises bliss levels by 70%, triples BDNF (brain-derived neurotrophic factors), and produces a bliss state 23% hi…" 1:33:10
A 21-minute daily practice raises bliss levels by 70%, triples BDNF (brain-derived neurotrophic factors), and produces a bliss state 23% higher than a sexual orgasm — based on studies from top universities. Sadhguru's point: bliss is not a luxury or a spiritual achievement. It is the natural chemistry of a well-run human system.
University research found that a simple 21-minute daily process taught by Sadhguru raises the practitioner's 'bliss factor' by 70%.
Studies at top universities found that people who practise Sadhguru's 21-minute Inner Engineering process register bliss levels 23% higher than those normally reached during a sexual orgasm.
The widely cited ego-depletion model — the idea that willpower is a finite resource that gets depleted — failed to replicate in follow-up studies.
Humans are estimated to have 5,000–7,000 thoughts per day, yet can recall essentially none of them afterward, highlighting why in-the-moment emotional tracking matters.
A large Harvard study found that a wandering mind is an unhappy mind — people report greater happiness when their attention is tethered to the present, even if the task is unpleasant.
A key study finding that we have a 'credit card's worth of plastic' in our bodies was likely skewed because researchers used nitrile gloves that shed plastic particles onto the microplastic detector.
Emotionally sensitive people have a hyperactive amygdala, an underactive prefrontal cortex, and a frayed connection between the two — making emotional regulation structurally harder.
Rejection sensitivity can be observed as early as age 2 or 3, suggesting it has strong developmental and likely genetic roots.
A Yale study found that non-judgmental observation of emotions — without rushing to resolve them — reduces activation in the brain, making it a powerful regulation tool.
Dan Gilbert's research found that the psychological immune system — the brain's ability to justify and find satisfaction in choices — activates most powerfully when a decision is perceived as irreversible.
Barry Schwartz's research found that maximizers — people who try to optimize every decision — tend to achieve objectively better outcomes but report lower happiness than satisficers who choose 'good enough.'
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