Dr. Patrick's evidence-based supplement stack: 2g omega-3s daily, a full-dose multivitamin, 4,000 IU vitamin D (70% of people are deficient), 250mg magnesium at night, and 10g creatine split across two doses. The creatine insight is surprising: only 5g reaches muscle — the second 5g crosses the blood-brain barrier and supports cognitive resilience.