Where this was said
The State of Longevity Science in 2025
At 3:29 · chapter starts 2:55
Sinclair takes stock of six years of progress since his first JRE appearance, noting that what sounded like science fiction in 2019 is now documented reality. Reversing aging — once a career-ending claim to make publicly — has been demonstrated in lab animals and is now entering human trials. Rogan marvels that the scientific establishment resisted the concept for so long, comparing it to how cancer was considered untreatable 200 years ago. Sinclair explains that his and his colleagues' key insight was identifying a common root cause of aging across cells — one that can not only be slowed but actively reversed. The discovery that there are genes capable of this reversal, and that it can be done safely, is what made everything else possible.
Sinclair's lab is running the first FDA-approved human trial to reverse aging using virus-like capsules carrying OSK genes. The first patient — nearly totally blind — received trillions of these capsules injected into his eye, and so far nothing has gone wrong.
