Quote · The Peter Attia Drive
#399 ‒ The evolution of Alzheimer's disease and dementia care: how early detection, personalized treatment, new therapies, and a multimodal approach are changing the landscape | Gayatri Devi, M.D.
Where this was said
Risk factors for Lewy body dementia
At 1:36:41 · chapter starts 1:36:15
Gayatri Devi outlines what is known about Lewy body risk factors: family history (when the diagnosis is correct), vascular risk factors, Alzheimer's pathology itself, Parkinson's disease, and even essential tremor — which sits on the same pathological spectrum. However, she is candid that the evidence base for Lewy body disease is far thinner than for Alzheimer's, and many purported risk factors may reflect shared underlying mechanisms rather than direct causality. The male predominance in Lewy body may partly be an artifact of Parkinson's misclassification skewing the denominator. She applies the universal principle: whatever is good for cardiovascular health is good for the brain, regardless of the specific dementia pathology.
Menopausal women have estrogen levels below 30–35 pg/dL; a 21-year-old patient of Gayatri Devi with severe brain fog had an estrogen level of just 22 pg/dL.
