Lex Fridman Podcast

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#497 – Biggest Mysteries in Physics: Antimatter, Dark Energy & ToE – Don Lincoln

Explore episode May 29, 2026

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Antimatter

At 2:11:19 · chapter starts 1:57:45

Dirac's prediction, Anderson's 1932 discovery, Fermilab's antiproton stash, the $1.5 quadrillion cost of a gram, CERN's 2023 antigravity test, and the one-in-a-billion matter surplus that explains why the universe exists.

Science
Producing Antimatter: The Most Expensive Substance in History

#497 – Biggest Mysteries in Physics: Antimatter, Dark Energ… · May 29, 2026 Science

At Fermilab's peak, producing one antiproton required smashing 100,000 protons into a target. The annual yield was about one nanogram. At that rate, producing a single gram of antimatter would take a billion years. NASA estimates the cost of 25 grams — equivalent to a 1-megaton explosion — at $1.5 quadrillion.

Science
The Neutrino Oscillation Race: Fermilab vs Japan

#497 – Biggest Mysteries in Physics: Antimatter, Dark Energ… · May 29, 2026 Science

Fermilab is racing Japan's neutrino facility to measure whether neutrinos and antineutrinos oscillate between their three types at slightly different rates. If they do, it could be the first experimental clue to why the early universe had a tiny surplus of matter over antimatter — and why the universe contains anything at all.

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