Grief vs. depression distinction
Grief and depression share symptoms like sleep disruption and appetite loss, but are distinctly different neurobiological processes.
Snapshot · Huberman Lab
Essentials: The Science & Process of Healing from Grief
Explore episode
May 28, 2026
Where this was said
Myths of Grief, Kubler-Ross & fMRI
At 1:56 · chapter starts 1:47
The five stages — denial, anger, bargaining, depression, acceptance — were treated as near-scripture for decades after Kübler-Ross published her landmark work on death and dying. Huberman acknowledges the genuine insight in her observations while making clear that neuroimaging has complicated the picture considerably. Brain imaging studies using fMRI, which tracks neural activity via blood flow, revealed something counterintuitive: the brain regions most powerfully activated during grief are those associated with motivation, craving, and pursuit — not the emotional processing regions the stage model would suggest. This reframes grief from a passive emotional journey through defined stages into an active, drive-like neurological state — one that explains the almost compulsive quality of yearning experienced after loss.
Kübler-Ross Was Partially Wrong
The famous five stages of grief — denial, anger, bargaining, depression, acceptance — were taken as immutable truth for decades. Modern fMRI research and clinical psychology have revealed they are neither universal nor sequential. Grief looks far messier, and more individual, than any neat stage model can capture.
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