Snapshot · Modern Wisdom
Research by Gould-Dolan at UC Berkeley suggests psychedelics reopen a critical neuroplasticity window lasting two to three weeks, during which habits — good or bad — are much more likely to stick.
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At 1:34:00 · chapter starts 1:26:22
If the UK were a US state, it would rank first in life expectancy, lowest homicide rate, gun deaths, prisoner population, healthcare coverage, paid maternity leave, statutory paid holiday, road deaths, and years in education. It would rank 51st — dead last — in GDP per capita. Americans, Chris found, had an excuse for every single data point except the money one.
A chart comparing the UK to US states showed the UK would rank first in life expectancy, homicide, and gun deaths but dead last — 51st — in GDP per capita.
Gould-Dolan at UC Berkeley has shown that psychedelics temporarily reopen critical developmental windows — the same neuroplasticity that exists in childhood. For two to three weeks after a psychedelic experience, your brain is unusually malleable. Habits formed in this window stick harder. This applies to stroke rehabilitation, language acquisition, and, critically, whatever you're doing at 11pm.
Tim Ferriss used accelerated TMS combined with the neuroplasticity agent D-cycloserine to drop his generalised anxiety and OCD rumination from an 8-9 out of 10 to near zero — in a single day. The effects lasted three to four months. It changed how fast he fell asleep, how easily he meditated, and how he processed the friction of daily life.
Dan Gilbert's research found that the psychological immune system — the brain's ability to justify and find satisfaction in choices — activates most powerfully when a decision is perceived as irreversible.
Barry Schwartz's research found that maximizers — people who try to optimize every decision — tend to achieve objectively better outcomes but report lower happiness than satisficers who choose 'good enough.'
Research consistently shows that while people may initially regret poor decisions, in the long run they regret the decisions they didn't make — inaction — far more than the ones they took.
A study showed that men in committed relationships who briefly viewed 10 attractive women's faces reported a measurable decrease in relationship satisfaction immediately afterward, illustrating evolutionary mismatch with modern media.
Harvard psychologist Dan Gilbert, who previously didn't believe in marriage, immediately proposed to his long-term girlfriend after his own research showed that constraints increase satisfaction with choices.
Animals first sensed light 540 million years ago, triggering an evolutionary acceleration known as the Cambrian explosion within 10 million years.
It is estimated that half of all cortical activity in the human brain is involved in visual function, underscoring vision's central role in intelligence.
Cognitive neuroscience literature shows that by age 6, humans can recognize tens of thousands of different object categories — far more data than early AI systems were trained on.
Only about 3% of FDA-approved drugs have genuinely unclear mechanisms of action, making an unknown mechanism a meaningful early red flag for any compound.
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