Snapshot · Pivot
New findings from the American Clinical Oncology gathering suggest GLP-1 drugs cut the growth rates of metastatic cancers in half, adding to a growing list of positive second-order effects.
Where this was said
At 48:20 · chapter starts 48:00
The GLP-1 conversation starts as an aside about SpaceX shorts and longs — Scott says if he had to go long any category it would be GLP-1s — and quickly becomes one of the episode's most substantive health segments. New findings from the American Clinical Oncology gathering show that metastatic cancer growth rates are cut in half in patients on GLP-1s. Potential delays in dementia and Alzheimer's are also being studied. Kara discloses that her cardiologist has already recommended a low dose for her after her stroke. Scott notes that every new GLP-1 study comes back with positive news — which is almost unprecedented for any major medical innovation. Externalities are usually negative (chemo causes leukemia, Big Tech causes polarisation), but GLP-1s keep surprising researchers. Both hosts predict the drug will move from 1 in 8 Americans to eventually 1 in 2, citing shifts in food consumption toward proteins and the market disruption for snack brands.
Every new study on GLP-1 drugs comes back positive. Data from the American Clinical Oncology gathering shows metastatic cancer growth rates are cut in half for patients on GLP-1s. Scott Galloway predicts 1 in 2 Americans will eventually be on some form of the drug.
Approximately one in eight Americans is currently taking a GLP-1 drug, with Scott Galloway predicting that figure could eventually reach one in two.
Spencer Greenberg and Jeremy Stevenson analyzed almost 500 self-improvement techniques and found they all reduce to just 12 underlying psychological drivers.
Cold exposure has good short-term alertness benefits but the evidence base for long-term health benefits is much weaker than popularly believed.
In a randomized study of 20 habit-formation techniques run on hundreds of people, almost none of the techniques produced statistically meaningful results.
People given a tiny-habit fallback option (e.g. 10 squats instead of gym) were actually MORE successful at completing the full habit, not less.
The most effective habit-formation technique was 'habit reflection' — recalling a past successful habit, writing down what helped, then applying those lessons to a new habit.
A study found that simply scheduling enjoyable activities was as effective as standard cognitive behavioral therapy for depression, leading to its own therapy called behavioral activation.
The 'worry time' technique — deferring all worries to a designated time of day — helps people realize they have more control over worry than they thought and reveals it is less useful than it feels.
A study found that participants told to try to stay awake while in bed fell asleep faster than participants told to try to sleep — illustrating the paradox of direct effort.
Spencer Greenberg reduced his severe social anxiety dramatically in roughly 6 months through a structured exposure therapy hierarchy, culminating in asking strangers for hugs.
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