Dax Shepard described how scientists have successfully reset the epigenome in mice to reverse aging and noted the first human trial of this approach has now begun.
Where this was said
At 1:55:40 · chapter starts 1:26:36
The Fact Check is wide-ranging. Monica confirms Edward Norton's middle name is Harrison, after his maternal grandmother Betty Kent Harrison — not after Harrison Ford. The $6.5 billion respiratory cost figure Norton cited for California port emissions turns out to be a national statistic from a 2011 study; the California-specific data shows diesel death zones have asthma hospitalization rates up to 8 times the county average and life expectancies up to 8 years lower. [1] — Monica Padman "RDJ MCU earnings: $386–$421M: Robert Downey Jr.'s reported total MCU salary ranges from $386 to $421 million, according to Comic Book Resou…" 2:05:35 Car efficiency data from major manufacturers is reviewed, with Tesla topping at 120.6 MPGe and Ford at 23.2 MPG, with Dax noting that trucks skew American brands' averages. The conversation pivots to Robert Downey Jr.'s Marvel earnings — $386 to $421 million total according to Comic Book Resources — and Dax's claim that Disney offered Johnny Depp $301 million to return to Pirates of the Caribbean after Depp had declared he'd never do it for $300 million.
While shooting Primal Fear, a young Norton was hoarding his per diem under his mattress, convinced the movie might be his last job. Richard Gere took him guitar shopping, found a 1969 Martin D-35, and bought it for Norton — telling him: 'You only live once. This won't be your last gig.'
Richard Gere owned one of the largest private guitar collections in the world at the time Norton knew him; it was later sold at Sotheby's for approximately $1.5 million.
Aging isn't in your DNA — it's in your epigenome, the layer above DNA that switches genes on and off and accumulates errors over time. Scientists have already reversed aging in mice by pruning the epigenome back to a pre-error state. The first human trial has now started. It is genuinely conceivable that people will one day select their own biological age.
At a vegan restaurant, Dax and Kristen hid an ultrasound photo in their menu to surprise Edward and Shawna Norton with their pregnancy news — only to flip their own menu over and reveal the same. The due dates were identical. Nobody believed it was real.
Animals first sensed light 540 million years ago, triggering an evolutionary acceleration known as the Cambrian explosion within 10 million years.
It is estimated that half of all cortical activity in the human brain is involved in visual function, underscoring vision's central role in intelligence.
Cognitive neuroscience literature shows that by age 6, humans can recognize tens of thousands of different object categories — far more data than early AI systems were trained on.
Only about 3% of FDA-approved drugs have genuinely unclear mechanisms of action, making an unknown mechanism a meaningful early red flag for any compound.
Even compounds that clear preclinical testing often fail in humans: 30 to 50% of drugs entering phase 1 trials do not advance to phase 2, frequently because human behavior differs from animal models.
More than 80% of published BPC-157 research comes from a single academic group whose researchers have IP and commercial interests connected to the molecule, limiting independent replication.
Roughly 100 peptide drugs are already FDA-approved, about 150 more are in clinical trials, and 600–700 are in preclinical development, underscoring the legitimacy of peptide science broadly.
The scientist who discovered BPC-157 refused to disclose the screening method used to identify the compound and has never fully published the parent protein sequence — what Peter Attia calls 'scientific trust me, bro.'
The brain's visual, auditory, and motor cortices light up nearly identically whether an experience is real or imagined, making visualization a form of actual neural training.
We use essential and analytics cookies to run Vuci. To understand how the site is used: Privacy Policy.
Install Vuci on your phone
Add it to your home screen for a faster, app-like experience.
Install Vuci on your phone
Tap the Share button, then “Add to Home Screen”.
A new version is available
Reload to get the latest Vuci.