Dax Shepard described how scientists have successfully reset the epigenome in mice to reverse aging and noted the first human trial of this approach has now begun.
Where this was said
At 1:55:40 · chapter starts 1:26:36
The Fact Check is wide-ranging. Monica confirms Edward Norton's middle name is Harrison, after his maternal grandmother Betty Kent Harrison — not after Harrison Ford. The $6.5 billion respiratory cost figure Norton cited for California port emissions turns out to be a national statistic from a 2011 study; the California-specific data shows diesel death zones have asthma hospitalization rates up to 8 times the county average and life expectancies up to 8 years lower. [1] — Monica Padman "RDJ MCU earnings: $386–$421M: Robert Downey Jr.'s reported total MCU salary ranges from $386 to $421 million, according to Comic Book Resou…" 2:05:35 Car efficiency data from major manufacturers is reviewed, with Tesla topping at 120.6 MPGe and Ford at 23.2 MPG, with Dax noting that trucks skew American brands' averages. The conversation pivots to Robert Downey Jr.'s Marvel earnings — $386 to $421 million total according to Comic Book Resources — and Dax's claim that Disney offered Johnny Depp $301 million to return to Pirates of the Caribbean after Depp had declared he'd never do it for $300 million.
While shooting Primal Fear, a young Norton was hoarding his per diem under his mattress, convinced the movie might be his last job. Richard Gere took him guitar shopping, found a 1969 Martin D-35, and bought it for Norton — telling him: 'You only live once. This won't be your last gig.'
Richard Gere owned one of the largest private guitar collections in the world at the time Norton knew him; it was later sold at Sotheby's for approximately $1.5 million.
Aging isn't in your DNA — it's in your epigenome, the layer above DNA that switches genes on and off and accumulates errors over time. Scientists have already reversed aging in mice by pruning the epigenome back to a pre-error state. The first human trial has now started. It is genuinely conceivable that people will one day select their own biological age.
At a vegan restaurant, Dax and Kristen hid an ultrasound photo in their menu to surprise Edward and Shawna Norton with their pregnancy news — only to flip their own menu over and reveal the same. The due dates were identical. Nobody believed it was real.
The widely cited ego-depletion model — the idea that willpower is a finite resource that gets depleted — failed to replicate in follow-up studies.
Humans are estimated to have 5,000–7,000 thoughts per day, yet can recall essentially none of them afterward, highlighting why in-the-moment emotional tracking matters.
A large Harvard study found that a wandering mind is an unhappy mind — people report greater happiness when their attention is tethered to the present, even if the task is unpleasant.
A key study finding that we have a 'credit card's worth of plastic' in our bodies was likely skewed because researchers used nitrile gloves that shed plastic particles onto the microplastic detector.
Emotionally sensitive people have a hyperactive amygdala, an underactive prefrontal cortex, and a frayed connection between the two — making emotional regulation structurally harder.
Rejection sensitivity can be observed as early as age 2 or 3, suggesting it has strong developmental and likely genetic roots.
A Yale study found that non-judgmental observation of emotions — without rushing to resolve them — reduces activation in the brain, making it a powerful regulation tool.
Dan Gilbert's research found that the psychological immune system — the brain's ability to justify and find satisfaction in choices — activates most powerfully when a decision is perceived as irreversible.
Barry Schwartz's research found that maximizers — people who try to optimize every decision — tend to achieve objectively better outcomes but report lower happiness than satisficers who choose 'good enough.'
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