A university study of 30,000 athletes found the improvement gap between doing nothing and doing a little exercise is enormous, while the gap between moderate and heavy training is very small.
Where this was said
At 2:08:00 · chapter starts 2:04:10
The episode's most science-forward and most comedically unhinged sequence runs together. Dax delivers a surprisingly lucid explanation of epigenome science: aging isn't driven by DNA change but by the accumulation of errors in the epigenome — the regulatory layer above DNA — that alter which genes get switched on or off. Mice have had their epigenomes pruned back to a pre-error state, effectively reversing their biological age. [1] — Dax Shepard "Aging isn't in your DNA — it's in your epigenome, the layer above DNA that switches genes on and off and accumulates errors over time. Scie…" 1:55:40 The first human trial has started. This launches a genuinely funny-dark hypothetical about what age Monica would reset to and the ethical and practical consequences — touching on consent, dating, egg retrieval, airline points as a parallel (Dax admits he's never used a single point), taste buds, and the Mike Nichols biography confirmation. A university study of 30,000 athletes concluding that the gap between no exercise and a little exercise is enormous rounds out the facts. Monica signs off by announcing the show is going on summer hiatus for Fact Checks.
Robert Downey Jr.'s reported total MCU salary ranges from $386 to $421 million, according to Comic Book Resources, not including cameo appearances.
Robert Downey Jr. reportedly earned $75 million for both Avengers: Infinity War and Avengers: Endgame individually.
Dax Shepard reported that Disney offered Johnny Depp $301 million to return for another Pirates of the Caribbean film after Depp had vowed never to return for under $300 million.
Mental health challenges are nearly universal — BetterHelp's own research found the majority of Americans experiencing symptoms right now.
When applying for Medicaid to cover nursing home costs, there is a 5-year look-back period that can disqualify applicants who gave away or spent down assets.
A broken pipe filled the Bad Friends studio with what the hosts identified as hydrogen sulfide — microscopic fecal aeroparticles — that the crew denied smelling.
Fei-Fei Li's father's liver surgery performed by a da Vinci robot resulted in 10 times less blood loss than a typical open liver surgery, thanks to laparoscopic precision.
Approximately 115 million adults in the US currently have prediabetes, most of whom are unaware, according to the Lingo sponsor segment.
Drug overdose deaths in the US fell from 110,000 to 80,000 in 2024, and then to roughly 70,000 — the largest single-year drop the CDC has ever recorded.
Men's overdose death rate fell 27% in a single year, outpacing the 23% drop for women.
The steepest decline in overdose deaths was among 15–24-year-olds, whose rate fell 37%.
Fei-Fei Li observed that on a given hospital shift, nurses walk miles just to fetch medicine and supplies, illustrating a clear use case for assistive robotics in healthcare.
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