Snapshot · The Peter Attia Drive
Lecanemab and donanemab each cost approximately $26,000 per year for the drug alone, with additional administration fees ranging from $400 to $10,000 per infusion.
Where this was said
At 1:01:41 · chapter starts 1:00:00
Aducanumab's approval in July 2021 was one of the most controversial FDA decisions in memory: the agency overruled its own advisory board, which found the amyloid-lowering effects did not translate reliably into clinical benefit. Gayatri Devi was nonetheless among the first physicians to prescribe it, applying her personal rule: would she want this drug if she had Alzheimer's herself [1] — Gayatri Devi "The other thing, Peter, I always ask myself anytime a new drug comes out is, would I want this drug? If I had Alzheimer's now, knowing ever…" 1:00:59 ? Her answer was yes — reasoning that even a small clinical benefit combined with disease-modifying amyloid clearance was worth trying, especially if the ARIA risk could be mitigated with slow titration. The drug was ultimately pulled from the market not because of safety failures but because the post-approval monitoring obligations became financially unviable for Biogen, leaving only lecanemab and donanemab in the field.
Anti-amyloid antibodies clear amyloid not just from brain substrate but also from the walls of small brain arteries. This disrupts vascular integrity, causing fluid leakage (ARIA-E, edema) and then actual blood extravasation (ARIA-H, hemorrhage). In severe cases with blood thinners or large vessel disruption, it can be fatal.
Mental health challenges are nearly universal — BetterHelp's own research found the majority of Americans experiencing symptoms right now.
When applying for Medicaid to cover nursing home costs, there is a 5-year look-back period that can disqualify applicants who gave away or spent down assets.
A broken pipe filled the Bad Friends studio with what the hosts identified as hydrogen sulfide — microscopic fecal aeroparticles — that the crew denied smelling.
Fei-Fei Li's father's liver surgery performed by a da Vinci robot resulted in 10 times less blood loss than a typical open liver surgery, thanks to laparoscopic precision.
Approximately 115 million adults in the US currently have prediabetes, most of whom are unaware, according to the Lingo sponsor segment.
Drug overdose deaths in the US fell from 110,000 to 80,000 in 2024, and then to roughly 70,000 — the largest single-year drop the CDC has ever recorded.
Men's overdose death rate fell 27% in a single year, outpacing the 23% drop for women.
The steepest decline in overdose deaths was among 15–24-year-olds, whose rate fell 37%.
Fei-Fei Li observed that on a given hospital shift, nurses walk miles just to fetch medicine and supplies, illustrating a clear use case for assistive robotics in healthcare.
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