Pinealon increases REM sleep
The peptide pinealon, taken 3 nights a week from a compounding pharmacy, can spectacularly increase REM sleep according to Huberman.
Snapshot · Modern Wisdom
Matt McCusker, Andrew Huberman & Tom Segura - Mostly Wise #1 - #1102
Explore episode
May 25, 2026
Where this was said
The Best Method to Optimise Your Sleep
At 1:43:38 · chapter starts 1:38:38
Andrew Huberman's Full Non-Pharmaceutical Sleep Protocol
Hot shower before bed lowers core body temperature via compensatory thermoregulation. Long deliberate exhales activate the vagus nerve and slow heart rate. A magnesium-saffron-apigenin stack handles the supplement side. For advanced users: pinealon peptide, 3 nights a week, from a compounding pharmacy — Huberman calls the REM sleep effect 'spectacular'.
Hot shower paradoxically aids sleep
A hot shower before bed paradoxically lowers core body temperature via compensatory thermoregulation, which is a necessary prerequisite for sleep onset.
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