All-In's Best Ideas Pitch Competition: 4 Investors Present Their Top Trades Live

All-In's Best Ideas Pitch Competition: 4 Investors Present Their Top Trades Live

Talen Energy trades at a $25B enterprise value vs. $45B replacement cost — buying it today is like buying the grid at half price before AI forces a power supercycle.

Jun 12, 2026 1:07:57 Difficulty: Intermediate Played

TL;DR

At the All-In Liquidity Summit's Best Ideas Pitch Competition, four professional investors presented their top trades live. Aaron Cowen (Suvretta Capital) pitched MGM Resorts as a hidden Asian casino play with Barry Diller's bid providing a floor; Dan Dreyfus (Bornite Capital) made the case for Talen Energy as a nuclear and gas power producer trading at a steep discount to replacement cost; Oleg Nodelman (EcoR1) introduced Aktis Oncology's radiopharmaceutical platform as a potential billion-dollar biotech; and Kyle Samani (Multicoin) pitched GEODNET, the world's largest RTK precision-location network, as a capital-efficient crypto asset. MGM won the bestie vote; Talen won the audience vote.

#MGM Resorts Japan casino #Talen Energy nuclear #GEODNET RTK network #Aktis Oncology radiopharmaceuticals #AI power demand #Barry Diller bid #DePIN crypto #power supercycle #biotech valuation #hedge fund stock picks #replacement cost investing #Sam Zell framework #GLP-1 longevity #data center power #PJM grid #MGM Resorts #Talen Energy #GEODNET #Aktis Oncology #Barry Diller #RTK network #radiopharmaceuticals #nuclear power #crypto token #Japan casino #power cycle #DePIN #biotech #hedge fund pitches

All-In's Best Ideas Pitch Competition features four professional investors pitching their top trades live at the All-In Liquidity Summit: Aaron Cowen (Suvretta Capital) on MGM Resorts, Dan Dreyfus (Bornite Capital) on Talen Energy, Oleg Nodelman (EcoR1 Capital) on Aktis Oncology, and Kyle Samani (Multicoin Capital) on GEODNET.

Chapter list
  • Chamath explains the Best Ideas Pitch Competition format, modeled on the Sohn Foundation conference. He recounts his own pitches: Amazon (2015), Tesla (2016), and the infamous Box-over-NVIDIA call in 2017.

  • Aaron Cowen pitches MGM Resorts as an Asian casino play: Barry Diller's 26% stake and $48 bid provide a floor, while a 2030 Osaka casino and Dubai optionality could push the stock from $48 to $100–$150.

  • Dan Dreyfus explains the anatomy of a power cycle and argues the US faces a mandatory AI-driven energy buildout. Talen Energy — 2 GW nuclear + 6 GW gas — trades at $25B EV vs $45B replacement cost.

  • Oleg Nodelman uses a military analogy to explain the history of cancer treatment before pitching Aktis Oncology — a radiopharmaceutical biotech with clinical data due in 2027 and Eli Lilly as a strategic backer.

  • Kyle Samani pitches GEODNET — the world's largest decentralized RTK network — covering 80% of the global population with 22,000 nodes, $11M ARR growing 3x annually, and 80% revenue used to buy back GEO tokens.

  • Chamath, Jason, Friedberg, and guest Gavin Baker give feedback and rank the pitches. The audience of 150 gives 50% to Talen; the bestie vote flips the result and MGM wins.

RTK (Real-Time Kinematics)
A GPS enhancement technique that achieves centimeter-level positioning accuracy (~2cm) versus standard GPS's ~2-meter precision, by using a fixed base station to correct satellite signal errors in real time.
DePIN (Decentralized Physical Infrastructure Network)
A crypto model where token incentives are used to crowdsource the build-out of real-world physical infrastructure (antennas, sensors, nodes) rather than relying on a single company to deploy it.
PPA (Power Purchase Agreement)
A long-term contract where a buyer (like a data center or utility) agrees to purchase electricity at a fixed price for a set period, often 10–20 years, from a power producer.
PJM
Pennsylvania-Jersey-Maryland Interconnection, a regional transmission organization coordinating the movement of wholesale electricity across 13 US states and DC — one of the world's largest electricity markets.
EBITDA
Earnings Before Interest, Taxes, Depreciation, and Amortization — a proxy for operating cash flow commonly used to value capital-intensive businesses like casinos and power plants.
Enterprise Value (EV)
The total value of a company including debt and minus cash — a broader measure of a company's market value than stock market capitalization alone, often used in acquisition math.
Radiopharmaceutical
A drug that combines a targeting molecule with a radioactive payload to deliver precisely localized radiation therapy directly to cancer cells while minimizing damage to healthy tissue.
Nectin-4
A protein expressed on the surface of bladder cancer cells that serves as a drug target; Aktis Oncology's first clinical program uses a mini-protein to deliver a radioactive payload to Nectin-4-expressing tumors.
B7H3
A protein expressed on nearly all major solid tumors (prostate, colorectal, lung); Aktis Oncology's second program targets B7H3, making it potentially applicable across multiple cancer types.
NAV (Net Asset Value)
The total value of an investor's portfolio or a company's assets minus liabilities; Aaron Cowen noted MGM represents 80% of Barry Diller's NAV, indicating deep personal conviction.
LCOE (Levelized Cost of Energy)
A measure of the average net present cost of electricity generation over a plant's lifetime, used to compare the economics of different power generation technologies.
CCGT (Combined Cycle Gas Turbine)
A highly efficient natural gas power plant that uses both a gas turbine and a steam turbine to generate electricity, commonly used for baseload power generation.
IPP (Independent Power Producer)
A private company that owns and operates electricity-generating facilities and sells power into the wholesale market, as opposed to a regulated utility; Talen Energy is an IPP.
Merchant IPP
An independent power producer that sells electricity at unregulated spot market prices rather than under long-term fixed contracts, resulting in higher but more volatile revenue.
Fully Diluted Market Cap
The total market value of a token or company assuming all possible tokens/shares have been issued, including those locked, vested, or not yet in circulation; used to give a more complete valuation picture.
Actinium
A radioactive element used as a payload in radiopharmaceuticals; Aktis Oncology uses actinium, which is derived from US Cold War nuclear waste and is not readily available in China.
GLP-1 (Glucagon-Like Peptide-1)
A class of drugs originally developed for type 2 diabetes (e.g., semaglutide/Ozempic, tirzepatide) that induce significant weight loss via appetite suppression, now being studied for longevity effects.
Sohn Foundation Conference
A prestigious New York-based investor conference modeled on the late Ira Sohn where leading hedge fund managers present their best investment ideas; a key inspiration for the All-In Best Ideas format.
Pachinko
A Japanese mechanical game resembling a vertical pinball machine used for recreational gambling, one of the main legal gambling activities in Japan before casino legalization.
Magnum opus
Latin for 'great work'; the most important or ambitious work of a person's career. Used here by Chamath to describe his intended career-defining investment pitch at the Sohn conference in 2017.

Chapter 1 · 00:00

Chamath explains the Best Ideas format

Chamath explains the Best Ideas Pitch Competition format, modeled on the Sohn Foundation conference. He recounts his own pitches: Amazon (2015), Tesla (2016), and the infamous Box-over-NVIDIA call in 2017.

Chapter 2 · 02:31

Suvretta Capital's Aaron Cowen pitches MGM Resorts

Aaron Cowen pitches MGM Resorts as an Asian casino play: Barry Diller's 26% stake and $48 bid provide a floor, while a 2030 Osaka casino and Dubai optionality could push the stock from $48 to $100–$150.

Chapter 3 · 13:07

Bornite Capital's Dan Dreyfus pitches Talen Energy

Dan Dreyfus explains the anatomy of a power cycle and argues the US faces a mandatory AI-driven energy buildout. Talen Energy — 2 GW nuclear + 6 GW gas — trades at $25B EV vs $45B replacement cost.

Chapter 4 · 27:19

EcoR1 Capital's Oleg Nodelman pitches Aktis Oncology

Oleg Nodelman uses a military analogy to explain the history of cancer treatment before pitching Aktis Oncology — a radiopharmaceutical biotech with clinical data due in 2027 and Eli Lilly as a strategic backer.

Health & Fitness
Oleg Nodelman Explains Radiopharmaceuticals as Micro-Drone Warfare

All-In's Best Ideas Pitch Competition: 4 Investors Present … · Jun 12, 2026 Health & Fitness

Chemo is carpet bombing. Immunotherapy is recruiting local allies. Radiopharmaceuticals are micro drones: 2-centimeter precision, single-cell blast radius, autonomous targeting. Aktis Oncology has built the platform to deliver any radioactive payload to any target — and the data readout is less than a year away.

Health & Fitness
Aktis Oncology: $500M EV, $10B Potential, Data in 2027

All-In's Best Ideas Pitch Competition: 4 Investors Present … · Jun 12, 2026 Health & Fitness

Aktis Oncology has a $500M enterprise value, cash to last 3+ years, and initial clinical data coming in Q1 2027. If one program hits, the company could be worth $10 billion — or get acquired by Lilly, which backstopped its IPO with $100M. The moat: China can't replicate actinium-based radiopharmaceuticals.

Technology
GEODNET: The Decentralized Precision GPS Network for the Physical AI Era

All-In's Best Ideas Pitch Competition: 4 Investors Present … · Jun 12, 2026 Technology

GEODNET has 22,000 base stations in 150 countries covering 80% of the global population — built in 4 years using a crypto incentive model where anyone can earn GEO tokens by hosting a node. It powers John Deere, DJI, TomTom, and robotic lawn mowers, and trades at $150M fully diluted on $11M ARR growing 3x YoY.

Chapter 5 · 40:20

Multicoin Capital's Kyle Samani pitches GEODNET

Kyle Samani pitches GEODNET — the world's largest decentralized RTK network — covering 80% of the global population with 22,000 nodes, $11M ARR growing 3x annually, and 80% revenue used to buy back GEO tokens.

Chapter 6 · 54:50

The Besties recap the pitches and announce winners

Chamath, Jason, Friedberg, and guest Gavin Baker give feedback and rank the pitches. The audience of 150 gives 50% to Talen; the bestie vote flips the result and MGM wins.

Business
The Besties Recap: MGM Wins the Bestie Vote, Talen Wins the Audience

All-In's Best Ideas Pitch Competition: 4 Investors Present … · Jun 12, 2026 Business

The audience of 150 investors gave 50% of votes to Talen Energy's Dan Dreyfus. But the bestie vote flipped the result: MGM's Aaron Cowen won on downside protection (Barry's bid) plus Japan and Dubai upside. GeoNet placed last on liquidity concerns; Aktis and GeoNet are lottery tickets, MGM and Talen are sizeable bets.

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Claims & Sources

2 / 20 cited (10%)

Factual claims made this episode, and whether a source was named.

Barry Diller owns 26% of MGM Resorts and has placed a formal bid at $48 per share.

Aaron Cowen no source cited

MGM Resorts has bought back approximately half of its float over the past 6 years.

Aaron Cowen no source cited

Japan's gambling market is approximately $40 billion, larger than Macau ($30B) and Las Vegas ($10B).

Aaron Cowen no source cited

MGM owns a license to open a casino in Osaka, Japan opening in 2030, in which they own a 40% stake and receive a management fee.

Aaron Cowen no source cited

Talen Energy has 2 gigawatts of nuclear power and 6 gigawatts of natural gas baseload power.

Dan Dreyfus no source cited

Talen Energy trades at a $25 billion enterprise value versus a $45 billion replacement cost.

Dan Dreyfus no source cited

China currently has 3 times the power generation capacity of the United States, having reversed a position where the US had 2x China's capacity.

Dan Dreyfus no source cited

The PJM grid operator forecasts a need for 106 gigawatts of new power in just the Pennsylvania-Jersey-Maryland region over the next 10 years.

Dan Dreyfus PJM grid operator forecast

Microsoft signed a 20-year PPA with Constellation Energy to restart the Three Mile Island nuclear reactor at $100/MWh, double the market rate of $50/MWh.

Dan Dreyfus no source cited

Jensen Huang was recently quoted saying we need 1,000 times more power than we currently have.

Dan Dreyfus Jensen Huang / NVIDIA public statement

EcoR1 Capital has generated a 10x return for investors since its 2013 inception, compounding at 20% annually, growing from $13M to $2.5B AUM.

Oleg Nodelman no source cited

Aktis Oncology's $300 million IPO was 18 times oversubscribed and received a $100 million backstop order from Eli Lilly.

Oleg Nodelman no source cited

There has been $15 billion in radiotherapy M&A and deal-making in recent years, with major pharma including Bristol, Novartis, Bayer, and Lilly actively building radiotherapy pipelines.

Oleg Nodelman no source cited

Caloric restriction is the only intervention shown in actual data to extend lifespan, and GLP-1 obesity drugs effectively mimic caloric restriction.

Oleg Nodelman no source cited

GEODNET was founded in 2021, has 22,000 base stations deployed in 150 countries covering 80% of the global population, making it the world's largest RTK network.

Kyle Samani no source cited

GEODNET has crossed $11 million in annualized run-rate revenue and is growing more than 3x year over year.

Kyle Samani no source cited

GEODNET uses 80% of its revenue — approximately $8.8 million annually — to buy GEO tokens on the open Solana market.

Kyle Samani no source cited

GEODNET's fully diluted market cap is approximately $150 million, with circulating market cap shown on price sites around $60-70 million due to unvested tokens.

Kyle Samani no source cited

Aktis Oncology's actinium radioisotope payload is derived from radium-233, a US Cold War nuclear waste product not available in China due to its different nuclear program history.

Oleg Nodelman no source cited

The Venetian Hotel in Las Vegas generates $1 million per day in incremental EBITDA when a show is running at the Sphere.

David Friedberg no source cited

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