- RTK (Real-Time Kinematics)
- A GPS enhancement technique that achieves centimeter-level positioning accuracy (~2cm) versus standard GPS's ~2-meter precision, by using a fixed base station to correct satellite signal errors in real time.
- DePIN (Decentralized Physical Infrastructure Network)
- A crypto model where token incentives are used to crowdsource the build-out of real-world physical infrastructure (antennas, sensors, nodes) rather than relying on a single company to deploy it.
- PPA (Power Purchase Agreement)
- A long-term contract where a buyer (like a data center or utility) agrees to purchase electricity at a fixed price for a set period, often 10–20 years, from a power producer.
- PJM
- Pennsylvania-Jersey-Maryland Interconnection, a regional transmission organization coordinating the movement of wholesale electricity across 13 US states and DC — one of the world's largest electricity markets.
- EBITDA
- Earnings Before Interest, Taxes, Depreciation, and Amortization — a proxy for operating cash flow commonly used to value capital-intensive businesses like casinos and power plants.
- Enterprise Value (EV)
- The total value of a company including debt and minus cash — a broader measure of a company's market value than stock market capitalization alone, often used in acquisition math.
- Radiopharmaceutical
- A drug that combines a targeting molecule with a radioactive payload to deliver precisely localized radiation therapy directly to cancer cells while minimizing damage to healthy tissue.
- Nectin-4
- A protein expressed on the surface of bladder cancer cells that serves as a drug target; Aktis Oncology's first clinical program uses a mini-protein to deliver a radioactive payload to Nectin-4-expressing tumors.
- B7H3
- A protein expressed on nearly all major solid tumors (prostate, colorectal, lung); Aktis Oncology's second program targets B7H3, making it potentially applicable across multiple cancer types.
- NAV (Net Asset Value)
- The total value of an investor's portfolio or a company's assets minus liabilities; Aaron Cowen noted MGM represents 80% of Barry Diller's NAV, indicating deep personal conviction.
- LCOE (Levelized Cost of Energy)
- A measure of the average net present cost of electricity generation over a plant's lifetime, used to compare the economics of different power generation technologies.
- CCGT (Combined Cycle Gas Turbine)
- A highly efficient natural gas power plant that uses both a gas turbine and a steam turbine to generate electricity, commonly used for baseload power generation.
- IPP (Independent Power Producer)
- A private company that owns and operates electricity-generating facilities and sells power into the wholesale market, as opposed to a regulated utility; Talen Energy is an IPP.
- Merchant IPP
- An independent power producer that sells electricity at unregulated spot market prices rather than under long-term fixed contracts, resulting in higher but more volatile revenue.
- Fully Diluted Market Cap
- The total market value of a token or company assuming all possible tokens/shares have been issued, including those locked, vested, or not yet in circulation; used to give a more complete valuation picture.
- Actinium
- A radioactive element used as a payload in radiopharmaceuticals; Aktis Oncology uses actinium, which is derived from US Cold War nuclear waste and is not readily available in China.
- GLP-1 (Glucagon-Like Peptide-1)
- A class of drugs originally developed for type 2 diabetes (e.g., semaglutide/Ozempic, tirzepatide) that induce significant weight loss via appetite suppression, now being studied for longevity effects.
- Sohn Foundation Conference
- A prestigious New York-based investor conference modeled on the late Ira Sohn where leading hedge fund managers present their best investment ideas; a key inspiration for the All-In Best Ideas format.
- Pachinko
- A Japanese mechanical game resembling a vertical pinball machine used for recreational gambling, one of the main legal gambling activities in Japan before casino legalization.
- Magnum opus
- Latin for 'great work'; the most important or ambitious work of a person's career. Used here by Chamath to describe his intended career-defining investment pitch at the Sohn conference in 2017.