Aktis IPO 18x oversubscribed, Lilly put in $100M
Aktis Oncology's $300M IPO was 18 times oversubscribed and backstopped by a $100 million order from Eli Lilly.
Snapshot · All-In with Chamath, Jason, Sacks & Friedberg
All-In's Best Ideas Pitch Competition: 4 Investors Present Their Top Trades Live
Explore episode
Jun 12, 2026
Where this was said
EcoR1 Capital's Oleg Nodelman pitches Aktis Oncology
At 35:40 · chapter starts 27:19
Oleg Nodelman uses a military analogy to explain the history of cancer treatment before pitching Aktis Oncology — a radiopharmaceutical biotech with clinical data due in 2027 and Eli Lilly as a strategic backer.
EcoR1 10x'd investors, 20% annualized since 2013
EcoR1 Capital has returned 10x to investors since its 2013 inception, compounding at 20% annually, growing from $13M to $2.5B AUM.
Oleg Nodelman Explains Radiopharmaceuticals as Micro-Drone Warfare
Chemo is carpet bombing. Immunotherapy is recruiting local allies. Radiopharmaceuticals are micro drones: 2-centimeter precision, single-cell blast radius, autonomous targeting. Aktis Oncology has built the platform to deliver any radioactive payload to any target — and the data readout is less than a year away.
Talon has 2 GW nuclear + 6 GW natural gas
Talen Energy owns 2 gigawatts of nuclear power and 6 gigawatts of natural gas baseload power.
Talen Energy: Buy Below Replacement Cost, Sell at a Premium
Talen Energy trades at a $25B enterprise value versus a $45B replacement cost. At 7x free cash flow on a $50/share FCF base, with comparable infrastructure at 15x, the equity should more than double just doing nothing. If power prices rise and data center deals accelerate, you get $1,050.
$25B EV vs $45B replacement cost
Talen Energy can be purchased at a $25B enterprise value while its replacement cost is $45B, implying the equity alone should more than double just to reach replacement cost.
Similar snapshots
50% of U.S. adults report being lonely
The U.S. Surgeon General's 2023 report on loneliness found that half of American adults report feeling lonely, marking a widespread epidemic of social isolation.
Brain.fm increased focus brainwave activity by 119%
In a peer-reviewed study, Brain.fm's audio technology was shown to increase focus-related brainwave activity by 119%, according to the show's sponsor read.
Wealthier countries have highest rates of anxiety and depression
The Easterlin Paradox shows that wealthier nations — and the wealthiest neighborhoods within them — tend to have the highest rates of anxiety, depression, loneliness, and suicide.
More than 3 in 4 Americans report anxiety or depression
Mental health challenges are nearly universal — BetterHelp's own research found the majority of Americans experiencing symptoms right now.
Medicaid 5-year look-back rule
When applying for Medicaid to cover nursing home costs, there is a 5-year look-back period that can disqualify applicants who gave away or spent down assets.
Pipe broke → hydrogen sulfide studio air
A broken pipe filled the Bad Friends studio with what the hosts identified as hydrogen sulfide — microscopic fecal aeroparticles — that the crew denied smelling.
Robot surgery: 10x less blood loss
Fei-Fei Li's father's liver surgery performed by a da Vinci robot resulted in 10 times less blood loss than a typical open liver surgery, thanks to laparoscopic precision.
115M US adults have prediabetes
Approximately 115 million adults in the US currently have prediabetes, most of whom are unaware, according to the Lingo sponsor segment.
Drug overdose deaths: 110K to 80K to 70K
Drug overdose deaths in the US fell from 110,000 to 80,000 in 2024, and then to roughly 70,000 — the largest single-year drop the CDC has ever recorded.
