Tadalafil upregulates androgen receptors
Low-dose tadalafil may increase the number or sensitivity of androgen receptors, helping the body respond better to circulating testosterone.
Snapshot · Modern Wisdom
Matt McCusker, Andrew Huberman & Tom Segura - Mostly Wise #1 - #1102
Explore episode
May 25, 2026
Where this was said
Should All Men Be Taking Erectile Dysfunction Medication?
At 4:10 · chapter starts 0:00
Why Every Man Over 40 Should Consider Low-Dose Tadalafil
Low-dose tadalafil (2.5–5 mg/day) isn't just for erectile dysfunction. Stanford's chair of male sexual health says most men over 40 should take it for prostate perfusion, brain vasodilation, and upregulation of androgen receptors. The patent expired — it costs pennies as a generic.
2.5–5 mg tadalafil/day
Stanford's chair of male sexual health Mike Eisenberg recommends nearly every man over 40 take low-dose tadalafil daily for prostate perfusion and brain vasodilation.
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