Speaker
Tom Segura
Appearances over time
7 episodes
Episodes
7
Fat Tommy Vs Skinny Tom | 2 Bears, 1 Cave
Tom Poops The Bucket, Bert Shit The Bed | 2 Bears, 1 Cave
Patrice O’Neal Destroyed Me | 2 Bears, 1 Cave
Nick Kroll Convinced Netflix to Air Animated Animal Sex | 2 Bears, 1 Cave
Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102
The Bears Go Up In Smoke | 2 Bears, 1 Cave
The End Is Here w/ Ari Shaffir | 2 Bears, 1 Cave
Podcasts
Quotes & moments
Tom Segura says he never had insecurities about his body when he was at his heaviest, and only looked back at photos later and thought 'whoa, why didn't anyone say anything?'
Tom Segura lost 25 pounds during a film production simply by eating lightly due to being in every scene, then gained about 10 pounds back.
Tom Segura is having his stool tested at a lab to determine why his bowel movements are so unpredictable, requiring him to scoop samples into vials and refrigerate or freeze them.
Tom Segura attempted to tell Eddie Murphy a story about his late brother Charlie Murphy and a dinner conversation, only for Eddie to respond 'Is that the end of the story?'
Tom Segura and Matt McCusker confirm that masturbation after a high-stimulus performance is a widely used method among comedians to come down from the adrenaline spike and fall asleep.
Tom Segura recalls watching Bert Kreischer order 10 appetizers, 4 full entrées, and approximately 20 double drinks at a restaurant in Tallahassee after the Florida State–Alabama game.
Tom and Bert looked up that kratom's active compounds bind to the same opioid receptors targeted by morphine and oxycodone, acting like a stimulant at low doses and an opioid at high doses.
Antoine Lavoisier, known as the father of modern chemistry, was guillotined during the French Revolution's Reign of Terror, largely driven by his former career as a tax collector.
Around 70-80% of Black people have lactose non-persistence, meaning their bodies produce lower levels of the enzyme needed to digest lactose.
Tom Segura argued that horror films can become hits without a recognizable star attached, which almost never happens with other genres including comedy.
Tom Segura's DMT experience lasted only approximately 15 minutes, during which his entire visual field appeared as a black-and-white sketch.
Tom Segura disclosed he maintained a Duolingo language-learning streak for 4 years before deliberately stopping.
Tom Segura's resting heart rate is in the upper 30s, alarming enough that he had a full cardiac workup at Cedars-Sinai, which confirmed he simply has a very strong heart.
The owner of Chuckleheads comedy club in Bisbee, Arizona — Doug Stanhope's estranged best friend — killed his ex-wife's father and himself in March, causing the club to close.
The End features 7 full hour-long episodes of unfiltered storytelling from top-tier comedians.
Marc Andreessen publicly endorsed an internet figure called 'retardmaxx' who advocates for just handling your business without rumination. The counterintuitive argument: great historical figures weren't known for introspection — they were known for action. Sometimes the highest-performance move is to stop thinking and start doing.
After a high-stimulus performance, catecholamines (dopamine, norepinephrine, epinephrine) are cranked to 11. Orgasm triggers a prolactin surge that hammers dopamine down and shifts the nervous system into parasympathetic rest mode. Evolution hardwired this circuit — comedians just discovered it empirically.
Hot shower before bed lowers core body temperature via compensatory thermoregulation. Long deliberate exhales activate the vagus nerve and slow heart rate. A magnesium-saffron-apigenin stack handles the supplement side. For advanced users: pinealon peptide, 3 nights a week, from a compounding pharmacy — Huberman calls the REM sleep effect 'spectacular'.
Research shows that just seeing a great sleep score improves cognitive and physical performance the next day — even if the sleep was mediocre. The reverse is equally true. The implication: checking your Whoop every morning might be sabotaging you on bad days more than it helps you on good ones.
Love Island producers removed all clocks, changed car radio times, and took watches away from contestants to control their sleep-wake cycles. Chris Williamson connected this to Huberman's research on how manipulating sleep scores shapes behavior — Love Island was running an unsanctioned circadian experiment on its cast.
People are uploading years of text message history and photos into AI chatbots to recreate their exes. One woman says it satisfies her emotional needs and prevents her from rebooting contact. The concern: it keeps you perfectly frozen in the relationship, perpetually preventing closure — and your ex may own their likeness over that data.
The classic serial killer era of BTK, Bundy, and Dahmer required time, mobility, and anonymity. Ring doorbells, toll cameras, phone GPS, and omnipresent CCTV have eliminated all three. Criminals now get caught so fast that long-running sprees are essentially impossible.
Matt McCusker pointed out that falling is a multi-billion dollar lawsuit industry in the US — illustrated by a viral video of a man deliberately crawling under a collapsed gas station awning to fake an injury claim. Russell Peters' brother similarly got treated like a crime victim when he slipped at CBS because America is uniquely litigious about slips and falls.
Eleven Labs' flagship British AI voice 'Archer' is — based on a side-by-side comparison — trained heavily on Chris Williamson's voice. It's already being used in unauthorized product ads. Eleven Labs told his team the similarity score was too low to act on. Huberman says he has IP lawyers who can fix this.
Huberman defines clang associations — a symptom of psychosis where people link ideas by sound or visual similarity rather than evidence. In the wellness world, this shows up as 'walnuts look like a brain so they must be good for your brain.' He's not diagnosing people — but this pattern of thinking is a warning sign.
UV light is the enemy, but long-wavelength infrared and red light from the sun are critical for mitochondrial health and can even penetrate clothing. Use zinc oxide–only mineral sunscreen to block UV while preserving infrared benefits, avoid burning, and get natural sunlight especially in early morning and late afternoon when the UV index is low.
In the original Stanford marshmallow test, no child waited the full 15 minutes — a fact that never gets mentioned. Yet how long kids waited before eating still predicted better life outcomes. The finding does hold up under replication, and self-control can be built — but the common telling strips out important nuance.
Johnny Depp spent his entire reported $650 million fortune. The highlights include $75 million on 14+ residences, $30–40k/month on wine, and $3 million to blast his friend Hunter S. Thompson's ashes from a custom cannon. His comeback via the new Pirates of the Caribbean could earn him 9 figures from a gross revenue deal.
Tom Segura laid out the legitimate forensic case against the Epstein suicide ruling: he changed his will days before death, his hyoid bone broke in a way forensic pathologists say is more consistent with homicide than suicide, and narcissists statistically don't kill themselves. Huberman notes the government is inefficient at covering things up, but 'I don't know' remains the most honest answer.
Low-dose tadalafil (2.5–5 mg/day) isn't just for erectile dysfunction. Stanford's chair of male sexual health says most men over 40 should take it for prostate perfusion, brain vasodilation, and upregulation of androgen receptors. The patent expired — it costs pennies as a generic.
Analysis
What they talk about
- Comedy 38%
- Health & Fitness 31%
- Arts 13%
- Society & Culture 12%
- TV & Film 6%
Connections
Shows they appear on and people they share episodes with. Drag to explore.
